With Tuilagi set for another lengthy spell on the sidelines, we take a look at his previous injury record.
This current setback is a cruel blow for the England centre, whose career has been ravaged by injury since 2003.
February 2012: Missed two 6 Nations games with a hamstring problem.
September 2013: Out for six months after tearing a pectoral muscle in a Premiership match against Newcastle. Missing all but one game of the 2014 Six Nations Tournament.
September 2014: Injures groin in second league game of the season. Misses three games.
October 2014: Out for 15 months after a recurrence of groin injury in Champions Cup match against Ulster.
April 2016: Injures knee in Champions Cup semi-final defeat by Racing 92.
May 2016: On his first game back, injures groin in Premiership semi-final against Saracens. Misses England's tour of Australia.
September 2016: Damages groin in Tigers’ season opener, out for 2 months. Makes his return in a win over Bristol on 25th November.
January 2017: Injures right knee and tweaks his medial ligament just 7 minutes into Premiership game against Saracens, damages cruciate knee ligament and out for at least 6 months.
The Samoan-born centre is now ruled out of contention for the upcoming Six Nations campaign and British & Irish Lions tour to New Zealand.
A bitter blow to Eddie Jones' plans as Tuilagi had been included in the initial 33-man Six Nations squad to attend a two-day training camp this month.
Take a look at some of his best bits below!