Ireland coach Andy Farrell has made seven changes to the side that started against France in round 2 of the 2021 Six Nations Championship. There are two uncapped players in the replacements.
Craig Casey, who was on the bench for the game against France, and Ryan Baird are in line for their first international caps in Stadio Olimpico on Saturday afternoon.
Johnny Sexton returns to captain the side and partners Jamison Gibson Park in the halfback.
This weekend has come too soon for Conor Murray who is continuing his hamstring rehab.
Robbie Henshaw, who earns his 50th cap for Ireland, will again partner Garry Ringrose in the midfield. Henshaw made his Ireland debut against USA on the 2013 Summer Tour, a few days before his 20th birthday.
Hugo Keenan retains the No.15 jersey with James Lowe on the left wing and Jordan Larmour coming in on the right hand side.
A new front row combination of Dave Kilcoyne, Ronan Kelleher and Tadgh Furlong is set to start.
James Ryan returns to the second row to partner Iain Henderson.
Tadgh Beirne shifts to the backrow filling the blindside role with Will Connors at openside and CJ Stander at No.8.
The replacements for the weekend are Rob Herring, Cian Healy, Andrew Porter, Jack Conan, Billy Burns, Keith Earls and the uncapped duo of Baird and Casey
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