Guy Noves has introduced 13 new players to the French squad for this week's clash against Italy.
François Trinh-Duc, who made several appearances in last years tournament, lined out at outside centre for Toulon on Saturday.
Stade Français centre Jonathan Danty makes a return to the squad.
Djibirl Camara, Henry Chavancy and Brice Dulin all also return in the backs while among the forwards are Cyril Baille, Mohamed Boughanmi, Xavier Chiocci, Camille Chat, Fabien Sanconnie, Charles Ollivon, Louis Picamoles and Christopher Tolofua.
France have won only one of their three 6 Nations fixtures, losing narrowly to England in R1, beating Scotland in Paris before losing to Ireland in Dublin.
France squad to face Italy
Forwards: Uini Atonio, Cyril Baille, Eddy Ben Arous, Mohamed Boughanmi, Camille Chat, Xavier Chiocci, Kevin Gourdon, Guilhem Guirado, Paul Jedrasiak, Julien le Devedec, Bernard le Roux, Yoann Maestri, Charles Ollivon, Louis Picamoles, Fabien Sanconnie, Rabah Slimani, Christopher Tolofua, Sébastian Vahaamahina
Backs: Djibirl Camara, Henry Chavancy, Jonathan Danty, Brice Dulin, Gaël Fickou, Yoann Huget, Rémi Lamerat, Camille Lopez, Maxime Machenaud, Noa Nakaitaci, Baptiste Serin, Scott Spedding, François Trinh-Duc, Virimi Vakatawa