Coach Eddie Jones has tinkered with his team that were victorious at Murrayfield in Round 2 for their massive clash against the Irish at Twickenham on Saturday.
In the forwards, Joe Marler comes in on the loose-head and Courtney Lawes returns to the back-row to partner Sam Underhill and Tom Curry.
The English have welcomed the welcomed the return of Manu Tuilagi who slots into the outside centre berth, prompting a move for Jonathan Joseph to the wing.
Jones has been complementary of the Irish in the build-up to the encounter:
“Ireland are a very good team, extremely well-coached. They are a team we respect a lot. They will bring their usual physicality and under Andy Farrell they’ve opened up their game a little bit.”
Kick-off: 3pm local.
Sam Crean earns his first cap, joining Theo Dan and Luke Green in the front row for Saturday’s match-up against the Irish at Franklin’s Gardens.
Flanker Josh Gray and second row forward Hugh Tizard make their first starts of the competition in a pack that will be tested.
The bench sees the likes of Chunya Munga, Rob Farrar, Blake Boyland, and Will haydon-Wood, who could all get a first taste of Six Nations rugby.
Saturday promises to be a titanic struggle between these two unbeaten sides.
Hannah Botterman’s injury sees Detysha Harper included in the Red Roses for their sell-out fixture against Ireland on Saturday.
In other changes, Leanne Riley comes back in at scrumhalf while Katy Daly-McLean and Sarah McKenna are also included in the starting XV.
England will be confident going into the match after their drubbing of Scotland in Round 2.