Italy opened the scoring but it was then one-way traffic as eight-try Scotland crushed the Azzurri, delighting home captain Stuart Hogg.
Scotland captain Stuart Hogg hailed "a hell of a performance" but still felt his team could have bagged more points after they pummelled Italy 52-10 at Murrayfield.
The rampant Scots topped 50 points for the first time against the Azzurri and also clinched their biggest margin of victory in the rivalry between the teams.
They ran in eight tries and Hogg overcame early misfiring to finish with six conversions, having been pressed into action at fly-half in the absence of Finn Russell.
Defeats in Edinburgh earlier in the championship had knocked Scotland out of contention, with a 25-24 loss to Wales followed by a 27-24 setback against Ireland.
The Scots showed their capabilities by beating England at Twickenham, however, and they will finish their campaign against France in Paris on Friday.
Hogg told the BBC: "I think all week we talked about having a big reaction and showing a performance that represented us.
"At times we probably lacked that clinical edge and we didn't score as many as we'd like to, but I am chuffed to bits with that. The boys put in a hell of a performance and that's where we want to be.
"We've had a huge amount of confidence from the very beginning of this Six Nations. It's just the little things that have killed us and that's the things that have annoyed us.
"We've been in every single game and we've scored 24 points in the last two games and managed to come away with defeats, so that's been bitterly disappointing.
"Today, that was more like us. We know we can throw the ball around and have some fun and hopefully that gives us a big boost ahead of next week as well."
Flanker Hamish Watson made 21 carries and was named man of the match.
Because Italy scored the game's first try, Watson admitted there had been early jitters in the Scotland ranks. But three yellow cards for Italy players made Scotland's task all the more comfortable.
"We were a bit worried at the start," Watson said. "We probably took our time to get into it a bit, but when we did I thought we did really well and we were clinical when we got the ball. I thought it was a good performance by us overall.
"We said earlier in the week that we were pretty gutted after the last two home defeats and we needed to put it right today and I think we did that.
"Italy always come here with a lot of ambition and they're a very aggressive team. We knew it was going to be tough for the first 10 or 20 minutes, then we had to build into the game. It's nice to get a good scoreline as well."
Italy captain Luca Bigi, who scored that early try, saw his team complete another championship of five consecutive defeats.
They have now lost 32 matches in a row in the Six Nations, and Bigi said: "It was a tough championship. We are so far from where we want to be.
"Obviously we cannot compete with three yellow cards so discipline was a key of this game. Scotland played an outstanding game.
"We will keep working. We have to be focused on what we can control and discipline is one of those things. It's a tough moment for us, but we never give up."