Joe Launchbury and Mako Vunipola have been named in a 25-man England squad ahead of Saturday's Calcutta Cup showdown with Scotland.
The duo could return from injury, having been sidelined for the chastening loss to France in England's Six Nations opener.
Eddie Jones, who will name his 23-man matchday selection on Thursday, has cut Charlie Ewels and will be without injured duo Manu Tuilagi (groin) and Anthony Watson (calf).
Lock Launchbury is on the mend following a knee problem, while Vunipola missed the clash in Paris after suffering an issue with his eye.
Bath second row Ewels was substituted in the second half against France, when England were 24-0 down. They went on to claim a losing bonus point in a 24-17 defeat.
Both Manu Tuilagi and Anthony Watson will return to their clubs to continue their rehabilitation.
Luke Cowan-Dickie (Exeter Chiefs)
Tom Curry (Sale Sharks)
Ben Earl (Saracens)
Ellis Genge (Leicester Tigers)
Jamie George (Saracens)
Maro Itoje (Saracens)
George Kruis (Saracens)
Joe Launchbury (Wasps)
Courtney Lawes (Northampton Saints)
Lewis Ludlam (Northampton Saints)
Joe Marler (Harlequins)
Kyle Sinckler (Harlequins)
Will Stuart (Bath Rugby)
Sam Underhill (Bath Rugby)
Mako Vunipola (Saracens)
Elliot Daly (Saracens)
Ollie Devoto (Exeter Chiefs)
Owen Farrell (Saracens
George Ford (Leicester Tigers)
George Furbank (Northampton Saints)
Willi Heinz (Gloucester Rugby)
Jonathan Joseph (Bath Rugby)
Jonny May (Leicester Tigers)
Ollie Thorley (Gloucester Rugby)
Ben Youngs (Leicester Tigers)