Springbok training has been suspended for Monday following a positive test in the squad.
The players have been placed in preventative isolation prior to further PCR testing and a review of the testing data by the Medical Advisory Group (MAG).
Lood de Jager returned a positive outcome in scheduled testing and, because of his close contact with a number of squad members, the entire group has gone into isolation.
SA Rugby stated that an update will be issued following the review by the MAG and further testing.
The Springboks are set to take on Georgia on Friday at Ellis Park (19;00 local, 18:00 BST) in the second of their two tests against the European side ahead of the British and Irish Lions Series.
This is the second time COVID has disrupted the side's preparations after two positive cases, and a false positive, also suspended training for a day.
It's also a further blow to the Springboks' second-row stocks with Eben Etzebeth in doubt after picking up a rib injury against Georgia while RG Snyman is unlikely to feature against the Lions through injury.