Germany will host Samoa in Heidelberg with the two sides vying for a place at the Rugby World in Japan next year.
The home side has a mountain to climb if they wish to qualify without going through the repechage competition after they lost 66-15 to Samoa at the end of the last month.
Samoa, on the other hand, will feel as they are just 80 minutes away from qualifying for the World Cup where they would join hosts Japan, Ireland, Scotland and Russia in Pool A.
The loser of this Play-off will the four-team global repechage in November that will determine the 20th and final qualifier for Japan 2019.
The final spot in Pool A at Rugby World Cup 2019 will be decided on Saturday as @DRVRugby host @manusamoa in the second leg of their play-off.
Samoa lead 66-15 on aggregate after leg one in Apia.
Kick off at 1600hrs GMT+2
Follow on https://t.co/zptBY8jCkC pic.twitter.com/uI4vIjzwH0
— Rugby World Cup (@rugbyworldcup) July 11, 2018
Canada and Hong Kong are the only two teams that have confirmed their place in the competition so far, with Kenya or Namibia set to join them.
Namibia and Kenya have taken unassailable leads at the top of the Gold Cup standings and will face off in the final round of the competition with the victor claiming a spot at the Rugby World Cup as Africa 1 while the loser will compete in the repechage.