Johnny Sexton returned to Ireland's team and led Andy Farrell's side to their first win of the 2021 Six Nations.
Ireland kick-started their Six Nations campaign as they beat Italy for an eighth successive time in the competition, claiming a 48-10 bonus-point victory in Rome.
Having gone down to Wales and France in their opening matches – the first time Ireland had lost their first two games of a Six Nations campaign – Andy Farrell's men got their first win of the 2021 campaign on Saturday.
The returning Johnny Sexton was typically influential, on point with his kicking and integral to slick attacks as Ireland made it 21 wins from their last 22 Six Nations meetings with Italy.
Garry Ringrose, Hugo Keenan and Will Connors propelled Ireland to a 27-point haul in the first half, Ireland's best first-half total in a Test since February 2018, with CJ Stander and Keith Earls also getting in on the act to seal a routine triumph.
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Welcomed back into Ireland's line-up after missing the defeat to France due to a head injury, Sexton marked his 50th Six Nations appearance with a simple three-pointer five minutes in, moments after Paolo Garbisi nosed Italy ahead.
Sexton was adding two more points to his tally five minutes later, with Ringrose having picked a gap in Italy's defence to score the game's first try.
Another Sexton penalty edged Ireland further in front and despite some spirited Italy attacking, the visitors struck again as Ringrose turned provider for Keenan.
Ireland had a third try before half-time, Sexton combining with Jordan Larmour to feed Connors in the corner, though Italy managed to strike back through Johan Meyer.
Yet Italy's work was undone by sloppy defending immediately after the restart – Stander bundling his way over.
Italy's issues were compounded before the hour, substitute Giosue Zilocchi sent to the bin for an attempted ball steal.
Ireland appeared to have made their advantage count when Stander found the line again, only for the try to be disallowed for a knock-on.
Luca Bigi's booking handed Ireland a further boost, though, and Connors hauled himself over from a maul before Earls piled further misery on sorry Italy.
Perfect comeback for Sexton
Since his Six Nations debut, Sexton has missed just seven of a possible 57 matches in the championship, including Ireland's defeat to Italy in 2013.
Sexton successfully converted all eight of his kicks on Saturday, tallying up 18 points in total to give him a pristine record. The pace of the game was ideal for the 35-year-old, who also made eight tackles and 20 passes – the last of which played in Earls late on.
More misery for whipping boys Italy
Italy's losing run in the Six Nations now sits at 30 games, the longest of any side in the competition's history. Their last win at home was back in 2013, against Ireland (22-15).
They have now conceded a try-scoring bonus point in 18 of their 22 matches since such add-ons were introduced to the Six Nations in 2017.
Italy welcome Wales to the Stadio Olimpico on March 13, with Ireland facing Scotland in Edinburgh a day later.