England head coach Eddie Jones has thrown a selection curveball with three centres in his starting XV with Jonathan Joseph starting on the wing.
In the front row Joe Marler, Jamie George and Kyle Sinckler are named with George Kruis and Maro Itoje in partnership in the second row for the third round of the Guinness Six Nations at Twickenham Stadium (KO 3pm live on ITV1).
Courtney Lawes is named at blind-side flanker with Sam Underhill at openside and Tom Curry at number 8.
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Ben Youngs starts at scrum half with Willi Heinz named as a finisher. George Ford and captain Owen Farrell will play fly half and inside centre. Manu Tuilagi is named at outside centre, returning to the side after missing the Scotland match through injury.
Elliot Daly is selected at full back with Jonathan Joseph, who will win his 50th cap this weekend, and Jonny May on the wings.
Charlie Ewels is named as a finisher alongside hooker Luke Cowan-Dickie, props Ellis Genge and Will Stuart and lock Joe Launchbury. Ben Earl, who made his England debut against Scotland is also named in the match day 23, as is Henry Slade who returns from injury.